Research and References
Hypochlorous Acid (HOCl):
HOCl is a powerful, tissue-friendly solution naturally produced by white blood cells to combat bacteria, viruses, and yeasts.
Its antimicrobial properties help reduce inflammation, pain, and promote faster healing.
Unlike traditional disinfectants, HOCl is non-toxic and safe for frequent use.
The effect of nasal and oral breathing on airway collapsibility in patients with obstructive sleep apnea: Computational fluid dynamics analyses
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by repetitive collapse of the pharyngeal airway. Understanding how different breathing routes influence airway collapsibility is crucial for improving treatment strategies. This study investigates the effect of nasal and oral breathing on pharyngeal airway stability using computational fluid dynamics (CFD) simulations. By analyzing airflow patterns and pressure changes in patients with OSA, we aim to determine which breathing route contributes most to airway collapse.
Hypochlorous Acid; Exemption From the Requirement of a Tolerance (federalregister.gov)
The EPA's Hypochlorous Acid Interim Decision confirms that hypochlorous acid poses no aggregate risk to the general population, including infants and children, and is therefore exempt from tolerance requirements for residues in food. Since no numerical tolerance is being set, an analytical enforcement method is unnecessary. However, the EPA limits the concentration of hypochlorous acid in antimicrobial pesticide formulations used on food-contact surfaces to 200 ppm total available chlorine, ensuring compliance through the FIFRA pesticide registration process.
Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study
This pilot study evaluated the tolerability and effectiveness of xylitol nasal irrigation in patients with chronic rhinosinusitis. In a randomized, double-blinded crossover trial, 20 subjects used xylitol and saline irrigations for 10 days each, with a washout period in between. Among the 15 participants who completed the study, xylitol irrigation significantly improved SNOT-20 scores compared to saline (P = .0437), though VAS scores showed no difference. Xylitol was well tolerated, with only one case of transient stinging and a mild dislike of sweetness reported by three participants. The study suggests that xylitol irrigation may offer greater symptom relief than saline for chronic rhinosinusitis.
Improved Nasal Volume Utilizing Hyperosmotic Saline Xylitol Mixture (Effective Alternative or Adjunct to Decongestants and Antihistamines)
Study evaluates the effects of xylitol and saline (Xlear) nasal irrigation on soft tissue hypertrophy in the nasal complex. Results indicate a statistically significant increase in nasal volume for individuals aged 11-46 (P < 0.05), but not for those 47 and older. Unlike decongestants and antihistamines, Xlear does not cause rebound effects and offers a safe, cost-effective alternative for treating nasal obstruction. Improved nasal breathing can enhance sleep, respiratory health, and posture, potentially reducing facial pain, headaches, and jaw issues. Further research is needed to confirm these findings.
Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review
Xylitol, a low-calorie sugar alcohol, is best known for its dental benefits, but also supports skin, gut, immune, respiratory, and bone health. It enhances skin barrier function, gut microbiota balance, and bone mineral density, while its antimicrobial properties may reduce sinusitis and respiratory infections. Xylitol may aid in weight management, though evidence is limited. It is generally safe, but overconsumption (>20g) can cause digestive discomfort. Further human studies are needed to confirm its full benefits.
Effects of a low concentration hypochlorous Acid nasal irrigation solution on bacteria, fungi, and virus
Explores low-concentration hypochlorous acid (HOCl) as a bactericidal nasal irrigation solution for chronic sinusitis. A 0.85% NaCl solution was electrically treated to generate 3.5 ppm HOCl and tested on human nasal epithelial cells. Results showed no cytotoxicity and strong antimicrobial effects, eliminating 99% of bacteria and fungi (except Candida albicans) and reducing human influenza A virus by 3.2-log10. Findings suggest that HOCl is a safe and effective nasal irrigation option.
Xylitol treats nasal mucosa in rhinitis medicamentosa: an experimental rat model study
Examines xylitol's healing effects on rhinitis medicamentosa, a drug-induced nasal condition caused by prolonged nasal decongestant use. 30 Wistar rats were treated with oxymetazoline for 2 months, then given xylitol, mometasone, or saline for 15 days. Histopathological analysis showed xylitol and mometasone were both effective in restoring nasal mucosa, with no significant difference in efficacy. Findings suggest xylitol is a viable, cost-effective alternative to mometasone for treating rhinitis medicamentosa, warranting further research in humans.
Improved outcomes after low-concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis
In this randomized, controlled study evaluated the effectiveness of low-concentration hypochlorous acid (HOCl) nasal irrigation versus normal saline for pediatric chronic rhinosinusitis. Over 4 weeks, 26 patients completed the study, showing significant symptom improvement in both groups. While X-ray scores improved more in the HOCl group, overall symptom relief was similar. Findings suggest that HOCl nasal irrigation is an effective adjuvant treatment for pediatric sinusitis.
Low-concentration hypochlorous acid nasal irrigation for chronic sinonasal symptoms: a prospective randomized placebo-controlled study
Low-concentration hypochlorous acid (HOCl) nasal irrigation is an effective treatment for chronic rhinosinusitis (CRS). It significantly improves sinonasal symptoms within 1-2 weeks, showing greater relief compared to saline irrigation. While it helps reduce bacterial presence, its impact on nasal endoscopy findings remains similar to saline. HOCl offers a promising option for managing CRS symptoms.